Urämie durch kontinuierliche Verabreichung von Hypophysen-Hinterlappenhormon

Summary

Starving and thirsting rabbits were injected subcutaneously every three hours with two units of commercial posterior lobe extract (Glanduitrin Richter).

The concentration of the urines, as measured by nitrogen and freezing-point determinations, declined sharply after an initial rise of three or four days duration. This hyposthenuria was accompanied by an azotaemia of 300–500 mg%. Such values are observed otherwise only in the last stages of kidney insufficiency. The concentrating power of the kidneys of control animals deprived of food and water was not impaired, the rise of N.P.N. unimportant. The origin of this “posterior lobe uraemia” is discussed. Hyposthenuria and not oliguria was found to be the important feature of the condition.