Summary
White rats submitted to a purified diet without vitamin A develop normally with carotene. When these animals are treated with thiouracil they show trophic alterations analogous to these observed in animals submitted to a diet without vitamine or provitamine A. These disturbances are cured immediately when vitamine A or powdered thyroids are given; on the other hand they continue when the dose of carotene is augmented. Iodine too exercises a protective and curative effect with an antagonistic action to thiouracil.
The authors interpret these disturbances as due to an inhibition of the carotinase produced by thiouracil.
Literatur
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Nous sommes redevables aux représentants en Espagne de J. R. Geigy S.A., Bâle (Suisse) du méthyl-thiouracil employé dans ces expériences.
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Wendt, Klin. Wschr.14, 9 (1935).
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Canadell, J.M., Valdecasas, F.G. Action inhibitrice du thiouracil sur la carotine. Experientia 3, 35–36 (1947). https://doi.org/10.1007/BF02155122
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DOI: https://doi.org/10.1007/BF02155122