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Experientia

, Volume 3, Issue 1, pp 28–28 | Cite as

Synthèse des 5- et 7-trifluorométhyl-quinoléines

  • E. Pouterman
  • A. Girardet
Kurze Mitteilungen

Summary

Starting fromm-trifluorotoluidine, we have prepared both the 5- and 7-trifluoroquinolines. These are the first fluorinated quinolines ever prepared, where fluorine is in the side chain.

Their physical and chemical properties are described; the introduction of the trifluoromethyl group in the molecule of quinoline increases its stability and greatly diminishes the constant of ionization.

Literatur

  1. 1.
    Jantzen, Dechema Monographien (Berlin)48 (1932).Google Scholar
  2. 2.
    Gonze, Bull. Soc. chim. Belg.43, 504 (1934).Google Scholar
  3. 3.
    Felsing etBiggs, J. amer. chem. Soc.55, 3624 (1933).CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1947

Authors and Affiliations

  • E. Pouterman
    • 1
    • 2
  • A. Girardet
    • 1
    • 2
  1. 1.Laboratoire de chimie généraleUniversité de GandFrance
  2. 2.Ecole de pharmacieUniversité de LausanneFrance

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