Biomechanics of echothiophate-induced anatomic changes in monkey aqueous outflow system

  • Elke Lütjen-Drecoll
  • P. L. Kaufman
Article

Abstract

Cynomolgus monkeys underwent long-term topical treatment with echothiophate, echothiophate + atropine, or control solution. Echothiophate-treated eyes exhibited increased intraocular pressure, collapse and densification of the trabecular meshwork with accumulation of extracellular material in the cribriform region, alterations in the shape and orientation of Schlemm's canal and the ciliary muscle, and discontinuity between ciliary muscle bundles and trabecular beams. Atropine or ciliary muscle disinsertion with subsequent scar formation supporting the mesh posteriorly at least partially prevented these alterations. Only sometimes did discontinuing echothiophate treatment restore normal anatomy. Collectively, these findings indicate that the pathophysiology of structural alterations in the outflow apparatus induced by echothiophate (1) is mediated at least in part by an anterior segment muscarinic receptor, (2) involves mechanical factors and underperfusion of the meshwork, and (3) does not involve any direct toxic effect of echothiophate.

Keywords

Atropine Intraocular Pressure Muscarinic Receptor Anterior Segment Cynomolgus Monkey 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Elke Lütjen-Drecoll
    • 1
  • P. L. Kaufman
    • 2
  1. 1.Department of AnatomyUniversity of Erlangen-NürnbergErlangenFederal Republic of Germany
  2. 2.Department of OphthalmologyUniversity of Wisconsin Medical SchoolMadisonUSA

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