Experimental study on drug therapy of “traction retinal detachment” after posterior penetrating eye injury in the rabbit

  • W. Behrens-Baumann
  • M. Vogel
Article

Abstract

In an experimental study on rabbits, a standarized eye injury was created by using the “pars-plana incision model.” Subsequently, the effect of intravenous application of dexamethasone and penicillamine on traction retinal detachment was investigated. The two drugs were applied in varying concentrations and combinations (single and combined use in varying intervals), followed by a 3-month control period without medication. Clinical and histological findings showed that intravitreal instillation of 1.2 mg dexamethasone reduces the incidence of retinal detachment from 46% to 27%. Higher concentrations of dexamethasone, as well as the use of penicillamine or a combination of both substances, proved to enhance traction retinal detachment.

Keywords

Public Health Experimental Study Dexamethasone Drug Therapy Histological Finding 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abrams GW, Topping TM, Machemer R (1979) Vitrectomy for injury. The effect on intraocular proliferation following perforation of the posterior segment of the rabbit eye. Arch Ophthalmol 97: 743–748PubMedGoogle Scholar
  2. Algvere P, Kock E (1976) Experimental fibroplasia in the rabbit vitreous. Retinal detachment induced autologous fibroblasts. Graefe's Arch Clin Exp Ophthalmol 199: 215–222CrossRefGoogle Scholar
  3. Algvere P, Jonsson V, Svedbergh B (1981) Vascular damage in the anterior uvea induced by intravitreal autogenous blood. Graefe's Arch Clin Exp Ophthalmol 217: 273–283CrossRefGoogle Scholar
  4. Amiel D, Akeson WH, Harwood FL, Schmidt DA, Mechanic GL (1977) Effect of low dosage schedule ofD-penicillamine on collagen cross-linking in a nine week immobilized rabbit knee. Connect Tissue Res 5: 179–183PubMedGoogle Scholar
  5. Behrens-Baumann W (1983) Tierexperimentelle Untersuchungen zur medikamentösen Behandlung der massiven periretinalen Proliferation (MPP) nach penetrierender Augenverletzung. Habilitationsschrift, GöttingenGoogle Scholar
  6. Benson WE, Machemer R (1976) Severe perforating injuries treated with pars plana vitrectomy. Am J Ophthalmol 81: 728–739PubMedGoogle Scholar
  7. Binder S, Riss B, Skorpik C, Kulnig W (1983) Inhibition of experimental intraocular proliferation with intravitreal 5-fluouracil. Graefe's Arch Clin Exp Ophthalmol 221: 126–129CrossRefGoogle Scholar
  8. Binder S (1981) Gibt es eine medikamentose Alternative in der Behandlung der massiven periretinalen Proliferation? Klin Monatsbl Augenheilkd 179: 483–485PubMedGoogle Scholar
  9. Blumenkranz MS, Ophir A, Claflin AJ, Hajek A (1982) Fluorouracil for the treatment of massive periretinal proliferation. Am J Ophthalmol 94: 458–467PubMedGoogle Scholar
  10. Burke JM, Smith JM (1981) Retinal proliferation in response to vitreous hemoglobin or iron. Invest Ophthalmol 20: 582–592Google Scholar
  11. Burke JM, Sipos E, Cross HE (1981) Cell proliferation vitreous hemoglobin. Invest Ophthalmol 20: 575–581Google Scholar
  12. Cleary PE, Ryan SJ (1979a) Experimental posterior penetrating eye injury in the rabbit. I. Method of production and natural history. Br J Ophthalmol 63: 303–311Google Scholar
  13. Cleary PE, Ryan SJ (1979b) Method of production and natural history of experimental posterior penetrating eye injury in the rhesus monkey. Am J Ophthalmol 88: 212–220Google Scholar
  14. Cleary PE, Minckler DS, Ryan SJ (1980) Ultrastructure of traction retinal detachment in rhesus monkey eyes after a posterior penetrating ocular injury. Am J Ophthalmol 90: 829–845PubMedGoogle Scholar
  15. Colemann DJ (1982) Early vitrectomy in the management of the severely traumatized eye. Am J Ophthalmol 93: 543–551PubMedGoogle Scholar
  16. Constable IJ (1975) Pathology of vitreous membranes and the effect of hemorrhage and new vessels on the vitreous. Trans Ophthalmol Soc UK 95: 382–386PubMedGoogle Scholar
  17. Constable IJ (1977) Vitreous membrane formation. In: McPherson A (ed) New and controversial aspects of vitreoretinal surgery. C.V. Mosby, St. Louis, pp 53–58Google Scholar
  18. Constable IJ, Oguri M, Chesney CM, Swann DA, Colman RW (1973) Platelet-induced vitreous membrane formation. Invest Ophthalmol 12: 680–685PubMedGoogle Scholar
  19. Conway BP, Michels RG (1978) Vitrectomy techniques in the management of selected penetrating ocular injuries. Ophthalmology 85: 560–583PubMedGoogle Scholar
  20. Cornman J (1951) Selective damage to fibroblasts by desoxycortiosterone in cultures of mixed tissues. Science 113: 37–39PubMedGoogle Scholar
  21. Eagling EM (1974) Ocular damage after blunt trauma to the eye. Br J Ophthalmol 58: 126–140PubMedGoogle Scholar
  22. Eagling EM (1975) Perforating injuries involving the posterior segment. Trans Ophthalmol Soc UK 95: 335–339PubMedGoogle Scholar
  23. Eagling EM (1976) Perforation injuries of the eye. Br J Ophthalmol 60: 732–736PubMedGoogle Scholar
  24. Fastenberg DM, Diddie KR, Sorgente N, Ryan SJ (1982) A comparison of different cellular inocular in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93: 559–564PubMedGoogle Scholar
  25. Faulborn J, Birnbaum F (1974) Netzhautoperationen in Verbindung mit der Versorgung schwerer perforierender Verletzungen. Klin Monatsbl Augenheilkd 164: 111–116PubMedGoogle Scholar
  26. Faulborn J, Atkinson A, Olivier D (1977) Primary vitrectomy as a preventive surgical procedure in the treatment of severely injured eyes. Br J Ophthalmol 61: 202–208PubMedGoogle Scholar
  27. Forrester JV, Grierson J (1980) Repair in the rabbit vitreous after hemorrhage. In: Naumann GOH, Gloor B (eds) Wundheilung des Auges und ihre Komplikationen. Bergmann, Munich, pp 389–394Google Scholar
  28. Forrester JV, Edgar W, Prentice CRM, Forbes CD, Williamson J (1976) Intravitreal fibrinolyses in experimental vitreous hemorrhage. Exp Eye Res 22: 181–188CrossRefPubMedGoogle Scholar
  29. Forrester JV, Lee WR, Williamson J (1978a) The pathology of vitreous hemorrhage. I. Gross and histological appearences. Arch Ophthalmol 96: 703–710Google Scholar
  30. Forrester JV, Grierson J, Lee WR (1978b) Comparative studies of erythrophagocytosis in the rabbit and human vitreous. Graefe's Arch Clin Exp Ophthalmol 208: 143–148CrossRefGoogle Scholar
  31. Freilich DB, Lee PF, Freeman HM (1966) Experimental retinal detachment. Arch Ophthalmol 76: 432–436PubMedGoogle Scholar
  32. Ghartey KN, Tolentino FI, Freeman HM, McMeel JW, Schepens CL, Aiello LM (1980) Closed vitreous surgery. XVII. Results and complications of pars plana vitrectomy. Arch Ophthalmol 98: 1248–1252PubMedGoogle Scholar
  33. Grossfeld H, Ragan C (1954) Action of hydrocortisone on cells in tissue culture. Proc Soc Exp Biol Med 86: 63–68PubMedGoogle Scholar
  34. Haferkamp O (1980) Allgemeine Pathologie der Wundheilung. In: Naumann GOH, Gloor B (eds) Wundheilung des Auges und ihre Komplikationen. Bergmann, Munich, pp 11–20Google Scholar
  35. Heimann K, Paulmann H (1977) Vitrectomy after perforating injuries. Mod Probl Ophthalmol 18: 242–244PubMedGoogle Scholar
  36. Heimann K, Paulmann H (1982) Vitrektomie in der Verletzungschirurgie. In: Jacobi KW (ed) Aktuelle Ophthalmologie. Deutscher Ärzte-Verlag, Cologne, pp 17–31Google Scholar
  37. Hübner H (1982) Intravitreale Steroidinjektion. Fortschr Ophthalmol 79: 236–238PubMedGoogle Scholar
  38. Hutton WL, Snyder WB, Vaiser A (1976) Vitrectomy in the treatment of ocular perforating injuries. Am J Ophthalmol 81: 733–739PubMedGoogle Scholar
  39. Jessop JD, Vernon-Roberts B, Harris J (1973) Effects of gold salts and prednisolone on inflammatory cells. I. Phagocytic activity of macrophages and polymorphs in inflammatory exsudates studied by a ‘skin-window’ technique in rheumatoid and control patients. Ann Rheum Dis 32: 294–300PubMedGoogle Scholar
  40. Johnston S (1971) Perforating eye surgery: a five year survey. Trans Ophthalmol Soc UK 91: 895–921PubMedGoogle Scholar
  41. Junge U, Perings E, Lubrich E (1974) Hemmung von Fibroblastenkulturen durchD-Penicillamin. Klin Wochenschr 52: 749–796CrossRefPubMedGoogle Scholar
  42. Kreiger AE, Straatsma BR, Foos RY (1977) Incisional complications in pars plana vitrectomy. Mod Probl Ophthalmol 18: 210–223PubMedGoogle Scholar
  43. Machemer R (1981) Correspondence. Am J Ophthalmol 92: 133Google Scholar
  44. Mein C, Blumenkranz M (1982) Antiproliferative agents in traumatic detachment. ARVO abstracts. Invest Ophthalmol Vis Sci [Suppl] 22: 234PubMedGoogle Scholar
  45. Michels RG, Ryan SJ (1975) Results and complications of 100 consecutive cases of pars plana vitrectomy. Am J Ophthalmol 80: 24–29PubMedGoogle Scholar
  46. Moorhead LC (1983) Effects of β-aminoproprionitrile after posterior penetrating injury in the rabbit. Am J Ophthalmol 95: 97–109PubMedGoogle Scholar
  47. Müller US, Wagner H, Wirth W, Junge-Hülsing G, Hauss WH (1971) Die mesenchymsuppressive Wirkung vonD-Penicillamin. Arzneimittelforsch 21: 679–683PubMedGoogle Scholar
  48. Müller-Jensen K, Mandelcorn MS (1975) Membrane formation by autotransplanted retinal pigment epithelium (RPE). Mod Probl Ophthalmol 15: 228–234PubMedGoogle Scholar
  49. Nimni ME (1979) Penicillamine and collagen metabolism. Scand J Rheumatol [Suppl] 28: 71–78Google Scholar
  50. Nimni ME, Bavetta LA (1965) Collagen defect induced by penicillamine. Science 150: 905–907PubMedGoogle Scholar
  51. Oguchi C (1913) Über die Wirkung von Blutinjektionen in den Glaskörper nebst Bemerkungen uber die sog. Retinitis proliferans. Graefe's Arch Clin Exp Ophthalmol 84: 446–520Google Scholar
  52. Paulmann H, Behrendt K (1980) Experimented Pars-plana-Vitrektomie: Folgerungen für die klinische Praxis. Ber Dtsch Ophthalmol Ges 77: 587–591Google Scholar
  53. Pilkerton AR, Rao NA, Marak GE, Woodward SC (1979) Experimental vitreous fibroplasia following perforating ocular injuries. Arch Ophthalmol 97: 1707–1709PubMedGoogle Scholar
  54. Pratt WB, Aronow L (1966) The effect of glucocorticoids on protein and nucleic acid synthesis in mouse fibroblasts growing in vitro. J Biol Chem 241: 5244–5250PubMedGoogle Scholar
  55. Priestley GC (1980) Changes in the growth and metabolism of cells cultured from normal, sclerotic and rheumatoid connective tissue brought about byD-penicillamine and by sodium salicylate. J Invest Dermatol 74: 413–417CrossRefPubMedGoogle Scholar
  56. Pülhorn G, Teichmann KD, Teichmann I (1977) Intraocular fibrous proliferation as an incisional complication in pars-plana vitrectomy. Am J Ophthalmol 83: 810–814PubMedGoogle Scholar
  57. Radtke ND, Tano Y, Chandler D, Machemer R (1981) Simulation of massive periretinal proliferation by autotransplantation of retinal pigment epithelial cells in rabbits. Am J Ophthalmol 91: 76–87PubMedGoogle Scholar
  58. Rozen VB, Chernin LS (1965) Effects of different doses of glucocorticoids on the growth of monolayer cultures of connective tissue. Fed Proc 24: T861–862Google Scholar
  59. Ruhmann AG, Berliner DL (1965) Effect of steroids on growth of mouse fibroblasts in vitro. Endocrinology 76: 916–927PubMedGoogle Scholar
  60. Ruhmann AG, Berliner DL (1967) Influence of steroids on fibroblasts. II. The fibroblast as an assay system for topical anti-inflammatory potency of corticosteroids. J Invest Dermatol 49: 123–130PubMedGoogle Scholar
  61. Ryan SJ, Allen AW (1979) Pars-plana vitrectomy in ocular trauma. Am J Ophthalmol 88: 483–491PubMedGoogle Scholar
  62. Schmidt P, Pedersen B (1981) Perforating eye injuries. Visual results after 5 years. Acta Ophthalmol (Copenh) 59: 949–958Google Scholar
  63. Sugita G, Tano Y, Machemer R (1980) Intravitreal autotransplantation of fibroblasts. Am J Ophthalmol 89: 121–130PubMedGoogle Scholar
  64. Swann DA (1977) On the integrity of vitreous structure. In: Freeman HM (ed) Vitreous surgery and advances in fundus diagnosis and treatment. Appleton-Century-Crofts, New York, pp 3–14Google Scholar
  65. Tano Y, Sugita G, Abrams G, Machemer R (1980a) Inhibition of intraocular proliferations with intravitreal corticosteroids. Am J Ophthalmol 89: 131–136Google Scholar
  66. Tano Y, Chandler DB, Machemer R (1980b) Treatment of intraocular proliferations with intravitreal triamcinolone acetonide. Am J Ophthalmol 90: 810–816Google Scholar
  67. Tano Y, Chandler DB, McCuen BW, Machemer R (1981) Gluco-corticosteroid inhibition of intraocular proliferation after injury. Am J Ophthalmol 91: 184–189PubMedGoogle Scholar
  68. Topping TM, Abrams GW, Machemer R (1979) Experimental double-perforating injury of the posterior segment in rabbit eyes. The natural history of intraocular proliferation. Arch Ophthalmol (Chicago) 97: 735–742Google Scholar
  69. Trese MT, Spitznas M, Foos RY, Hall MO (1980) Experimental tractional retinal detachment in rabbits. Clinical picture and histopathologic features. Graefe's Arch Clin Exp Ophthalmol 214: 213–222CrossRefGoogle Scholar
  70. Weiss JF, Belkin M (1981) The effect of penicillamine on posttraumatic vitreous proliferation. Am J Ophthalmol 92: 625–627PubMedGoogle Scholar
  71. Wiedemann P, Kirmani M, Santana M, Sorgente N, Ryan AJ (1983) Control of experimental massive periretinal proliferation by daunomycin: dose-response relation. Graefe's Arch Clin Exp Ophthalmol 220: 233–235Google Scholar
  72. Winthrop SR, Cleary PE, Minckler DS, Ryan SJ (1980) Penetrating eye injuries: a histopathological review. Br J Ophthalmol 64: 809–817PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • W. Behrens-Baumann
    • 1
  • M. Vogel
    • 1
  1. 1.Department of OphthalmologyUniversity of GöttingenGöttingenFederal Republic of Germany

Personalised recommendations