Summary
The effects of adrenaline on human subjects can induce a histamine-counter-regulation, which appears after physiological or therapeutical adrenaline-doses.
The proved counter-regulation's effect offers a possibility for explanation of collaps-conditions after nerve block and after subcutaneous infiltration anaesthesia. This suggests the prevention of such incidences by anti-histamine-substances. The individual differences in the course of reaction may have clinical importance.
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Staub, H. Histaminämie nach Adrenalin. Experientia 2, 29–30 (1946). https://doi.org/10.1007/BF02154709
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DOI: https://doi.org/10.1007/BF02154709