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Substances thioloprives

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Summary

The author proposes to include in a new class of drugs: the “thioloprive drugs,” all those substances which react in one way or another, with the thiol functions of proteins, cysteine or glutathione. This class includes oxidizing agents, heavy metals, maleic acid and halogenated organic substances like mustard gas, lewisite or monoiodoacetic acid. The creation of this new pharmacological family is justified by the fact that these varied substances have many common toxic effects (Lundsgaard contracture, cytotoxic action, œdema), that they inhibit the same enzymes, and that a logical interpretation of many of their actions is possible on the basis of their reaction with the thiol groups.

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References

  1. E. Lundsgaard, Biochem. Z.217, 162 (1930) et227, 51 (1930).

    CAS  Google Scholar 

  2. Z. M. Bacq etM. Goffart, C. r. Soc. Biol.133, 694 et 696 (1940).

    CAS  Google Scholar 

  3. Z. M. Bacq, M. Goffart etP. Angenot, Bull. Acad. Roy. Med. Belg. 255 (1940).

  4. J. Godeaux, Bull. Soc. Roy. Sci. Liége 692 (1943).

  5. Z. M. Bacq, M. Goffart etP. Angenot, Bull. Acad. Roy. Med. Belg. 255 (1940).

  6. Z. M. Bacq, Bull. Acad. Roy. Med. Belg. 108 (1942).

  7. O. Krayer, R. P. Linstead etD. Todd, J. Pharm. exper. Ther.77, 113 (1943).

    CAS  Google Scholar 

  8. O. Krayer, Proc. Soc. exper. Biol. Med.53, 51 (1943).

    Article  CAS  Google Scholar 

  9. R. Mendez, J. Pharm. exper. Ther.81, 151 (1944).

    CAS  Google Scholar 

  10. Z. M. Bacq, Bull. Acad. Roy. Med. Belg., 108 (1942).

  11. Z. M. Bacq, Acta biol. Belg.2, 253 (1942).

    Google Scholar 

  12. J. Godeaux, Bull. Soc. Roy. Sci. Liége, 216 (1944).

  13. Z. M. Bacq, Bull. Acad. Roy. Med. Belg. 108 (1942).

  14. Z. M. Bacq, Bull. Acad. Roy. Med. Belg. 108 (1942).

  15. Z. M. Bacq, M. Goffart etP. Angenot, Bull. Acad. Roy. Med. Belg. 255 (1940).

  16. Z. M. Bacq etM. Goffart, Acta biol. Belg.1, 33 (1941).

    Google Scholar 

  17. O. Muntsch, Leitfaden der Pathologie und Therapie der Kampfstofferkrankungen, Thieme, Leipzig 1941.

  18. A. Rühl etS. Thaddea, Z. exper. Med.100, 306 (1937).

    Article  Google Scholar 

  19. W. Feldberg etC. H. Kellaway, Australian J. exper. Biol. med. Sci.16, 249 (1938).

    Article  CAS  Google Scholar 

  20. W. Heubner, Heffter Handb. exper. Pharm.III, 3, 2020 (1934).

    Google Scholar 

  21. B. v. Issekutz etI. Mehes, Arch. exper. Path. Pharm.152, 318 (1930).

    Article  Google Scholar 

  22. F. Flury, Heffter Handb. exper. Pharm.III, 3, 1885 (1934).

    Google Scholar 

  23. I. Berenblum, L. P. Kendall etG. W. Orr, Biochem. J.30, 709 (1936).

    Article  CAS  Google Scholar 

  24. A. Gilman etF. S. Philips, Science103, 409 (1946).

    Article  CAS  Google Scholar 

  25. F. S. Hammett, Protoplasma13, 331 (1931).

    Article  CAS  Google Scholar 

  26. W. Richter, Kampfstoffwirkung und Heilung, J. A. Barth, Leipzig 1941.

  27. W. Feldberg etC. H. Kellaway, Australian J. exper. Biol. med. Sci.16, 249 (1938).

    Article  CAS  Google Scholar 

  28. A. Gilman etF. S. Philips, Science103, 409 (1946).

    Article  CAS  Google Scholar 

  29. I. Berenblum etA. Wormall, Biochem. J.33, 75 (1939).

    Article  CAS  Google Scholar 

  30. V. Desreux, E. Fredericq etP. Fischer, Bull. Soc. Chim. biol., sous presse (1946).

  31. Z. M. Bacq, Enzymologia10, 48 (1941).

    CAS  Google Scholar 

  32. Z. M. Bacq, M. Goffart etP. Angenot, Bull. Acad. Roy. Med. Belg. 255 (1940).

  33. Z. M. Bacq, Arch. int. Pharm. Ther.63, 59 (1939) et67, 323 (1942).

    CAS  Google Scholar 

  34. Z. M. Bacq etG. Coppée, Arch. int. Physiol.51, 35 (1941).

    CAS  Google Scholar 

  35. R. A. Peters, L. A. Stocken etR. H. S. Thompson, Nature156, 616 (1945).

    Article  CAS  Google Scholar 

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  1. Liége

    Z. M. Bacq

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  1. Z. M. Bacq
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Bacq, Z.M. Substances thioloprives. Experientia 2, 385–390 (1946). https://doi.org/10.1007/BF02154210

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  • DOI: https://doi.org/10.1007/BF02154210

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