Summary
A method is described which makes quantitative studies of the action of Cortisone on connective tissue possible. Foreign body granulomas are provoked in rats by subcutaneous implantation of pellets of compressed cotton. Application of Cortisone results in a diminution of granuloma formation, which can be expressed quantitatively by determining the fresh and the dry weight. Cortisone was effective by local as well as by general application, similar concentrations producing the same degree of inhibition of connective tissue.
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Meier, R., Schuler, W. & Desaulles, P. Zur Frage des Mechanismus der Hemmung des Bindegewebswachstums durch Cortisone. Experientia 6, 469–471 (1950). https://doi.org/10.1007/BF02154110
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DOI: https://doi.org/10.1007/BF02154110