Several new basic substituted derivatives of phthalazine show a potent depressive action on blood-pressure which is characterized by a gradual beginning and a very long duration. This action is limited to a narrow range of dosages. The substances produce an increase in the renal blood-flow and have “adrenolytic” properties of a special character. This combination effects a mode of action not common to other blood-pressure depressing substances.
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N. L. Drake undR. M. Peck, J. Amer. Chem. Soc.68, 1313 (1946).
R. D. Haworth undSt. Robinson, J. Chem. Soc. 777 (1948).
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Gross, F., Druey, J. & Meier, R. Eine neue Gruppe blutdrucksenkender Substanzen von besonderem Wirkungscharakter. Experientia 6, 19–21 (1950). https://doi.org/10.1007/BF02154049