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Über einen Di-Cholinester mit hoher Curarewirksamkeit

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An Erratum to this article was published on 01 June 1951

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Summary

The bis-cholinester of adipinic acid exhibits nicotine like stimulating actions as well as neuromuscular and ganglionic blocking actions; this actions can be reinforced by cholinesterase inhibiting substances (Eserine, TEPP). This increase of activity depends on the inhibition of the enzymatic hydrolysis of M 111 by cholinesterase. In the non-anaesthetised animal prevails the neuromuscular blocking action as it is known for C10.

Under the condition of suitable inhibition of cholinesterase the true activity of this substance appears: in this case M 111 becomes more potent than C10 andd-tubocurarinchlorid in the preparations used, e.g. as measured on the rat-diaphragm, M 111 exceeds the activity of C10 thirty times.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Wien, Austria

    K. H. Ginzel, H. Klupp & G. Werner

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  1. K. H. Ginzel
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  2. H. Klupp
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  3. G. Werner
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Ginzel, K.H., Klupp, H. & Werner, G. Über einen Di-Cholinester mit hoher Curarewirksamkeit. Experientia 7, 72–74 (1951). https://doi.org/10.1007/BF02153836

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  • DOI: https://doi.org/10.1007/BF02153836

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