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Experientia

, Volume 7, Issue 2, pp 71–72 | Cite as

Wirkung des Ouabains auf das Aktomyosin der Herzmuskulatur

  • K. A. P. Edman
Kurze Mitteilungen

Summary

The action of ouabain in concentrations from 10−4 M to 10−7 M on the reaction between actomyosin and ATP has been investigated in both native extract and washed actomyosin from beef heart. The glycoside has a stimulating effect on myosin-ATP-ase, but inhibits the activity of ATP-ase in native muscle extract containing both water soluble and myosinbound ATP-ase. Furthermore, ouabain causes a change in the recovery phase of the viscosity curve, the extent of which depends on the Ca++ concentration.

References

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    A. Csapó, Acta Physiol. Scand.19, 100 (1949).Google Scholar
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    A. Szent-Györgyi, Acta Physiol. Scand.9, Suppl. 25 (1945).Google Scholar
  3. 2.
    W. W. Kielley undO. Meyerhof, J. Biol. Chem.174, 387 (1948).Google Scholar

Copyright information

© Birkhäuser Verlag 1951

Authors and Affiliations

  • K. A. P. Edman
    • 1
  1. 1.Pharmakologisches Institut der Universität UppsalaSwitzerland

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