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The synthesis of the purine nucleus byEscherichia coli, a study on the mode of action of sulfa-drugs

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Zusammenfassung

In Kulturen vonEscherichia coli, die durch Sulfonamidverbindungen gehemmt sind, wird 4-Amino-imidazol-5-carboxyamid (II) gebildet. Diese Substanz ist eine Zwischenstufe in der Biosynthese des Purin-(Xanthin-)Systems. Das fehlende Kohlenstoffatom C2 wird durch Methionin (III) geliefert. Der Überträger des Kohlenstoffatoms ist diep-Aminobenzoesäure. Cholin, Betain und Serin können das fehlende C2 nicht liefern. Äthionin (IV) verhält sich wie Methionin.

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Authors and Affiliations

  1. Weizmann Institute of Science, Rehovoth, Israel

    Ruth Ben-Ishai, Benjamin Volcani & Ernst D. Bergmann

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  1. Ruth Ben-Ishai
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  2. Benjamin Volcani
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  3. Ernst D. Bergmann
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Ben-Ishai, R., Volcani, B. & Bergmann, E.D. The synthesis of the purine nucleus byEscherichia coli, a study on the mode of action of sulfa-drugs. Experientia 7, 63–64 (1951). https://doi.org/10.1007/BF02153827

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