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In vivo perfusion of the human ovary with 4-14C-dehydroepiandrosterone and 7α-3H-dehydroepiandrosterone35S-sulfate. Biosynthesis of steroid hormones in human gonads, V

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  • Endocrinologica
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Zusammenfassung

Nach in-vivo-Perfusion eines menschlichen Ovars mit 4-14C-DHEA und 7α-3H-DHEA-35S-sulfat lagen rund 15% der freien C19- und C18-steroide im Ovarialvenenblut als3H- und 85% als14C-markierte Verbindungen vor. Die Fraktion der sulfokonjugierten Steroide, bestehend aus 60% Steroidsulfatiden und 40% Steroidsulfaten, enthielt etwa 69% doppeltmarkierte, 27%3H- und 4%14C-markierte Sulfokonjugate. Neben dem vorzugsweise direkten Metabolismus des sulfokonjugierten DHEA liess sich auch ein indirekter Stoffwechsel zu Androgenen und Östrogenen nachweisen.

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Authors and Affiliations

  1. Abteilung für Experimentelle Endokrinologie, Universitäts-Frauenklinik, 65 Mainz

    G. W. Oertel, L. Treiber, D. Wenzel, P. Knapstein, F. Wendlberger & P. Menzel

  2. Chirurgische Universitätsklinik, Universität des Saarlandes, 665 Homburg, Germany

    G. W. Oertel, L. Treiber, D. Wenzel, P. Knapstein, F. Wendlberger & P. Menzel

Authors
  1. G. W. Oertel
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  2. L. Treiber
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  3. D. Wenzel
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  4. P. Knapstein
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  5. F. Wendlberger
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  6. P. Menzel
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Additional information

This investigation was supported by the Deutsche Forschungsgemeinschaft, 532 Bad Godesberg (Germany)

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Oertel, G.W., Treiber, L., Wenzel, D. et al. In vivo perfusion of the human ovary with 4-14C-dehydroepiandrosterone and 7α-3H-dehydroepiandrosterone35S-sulfate. Biosynthesis of steroid hormones in human gonads, V. Experientia 24, 607–609 (1968). https://doi.org/10.1007/BF02153803

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