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Induction of pigmentary changes in the skin of the mongolian gerbil by chemical carcinogens

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  • Anatomica, Histologica, Carcinologica
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Zusammenfassung

Die wiederholte Auftragung von Krotonöl oder von 7, 12-Dimethylbenz(a)-Anthrazen (DMBA) ruft beim erwachsenen mongolischen Gerbillus eine deutliche Überpigmentierung der behaarten Bauchhaut hervor. In beiden Fällen geht die Überpigmentierung vornehmlich auf eine Vermehrung der Zahl der Hautmelanozyten zurück, die die Haarfollikel umgeben und sich zwischen diesen befinden. DMBA erzeugt im Gegensatz zu Krotonöl zahlreiche Papillome und aktive Melanozyten innerhalb der interfollikulären Oberhaut. In einem Fall hat sich bei einem mit DMBA and Krotonöl behandelten Gerbillus eine melanozytische Hautgeschwulst entwickelt.

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Authors and Affiliations

  1. Division of Biological and Medical Sciences, Brown University and Department of Medical Education, St. Joseph's Hospital, Providence, Rhode Island, USA

    W. C. Quevedo Jr., Theresa C. Bienieki, N. Fausto & S. I. Magalini

Authors
  1. W. C. Quevedo Jr.
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  2. Theresa C. Bienieki
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  3. N. Fausto
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  4. S. I. Magalini
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Additional information

Certain phases of this program were pursued in the Department of Anatomy, St. Mary's Hospital Medical School, London, during the tenure of an American Cancer Society Visiting Scholarship.

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Quevedo, W.C., Bienieki, T.C., Fausto, N. et al. Induction of pigmentary changes in the skin of the mongolian gerbil by chemical carcinogens. Experientia 24, 585–586 (1968). https://doi.org/10.1007/BF02153788

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  • DOI: https://doi.org/10.1007/BF02153788

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