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Pancreozymin/cholecystokinin a physiological mediator of gastric secretory inhibition of duodenal origin

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  • Physiologica
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Résumé

La Pancréozymine-cholécystokinine (PZ) augmente la sécrétion de l'acide gastrique stimulée par la méthacholine, mais diminue la réponse acide à la gastrine pentapeptide. L'acidification de l'anse Thiry-Vella du duodénum fait augmenter pareillement la sécrétion acide de la poche d'Heidenhain stimulée par la méthacholine et la diminue quand le stimulant est de la gastrine pentopeptide. Il est bien connu que l'acidification du duodénum libère le PZ de la muqueuse duodénale. Nos résultats suggèrent que le PZ est l'agent médiateur d'abaissement de l'acidité gastrique après acidification du duodénum.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Creighton University Medical School, 68131, Omaha, Nebraska, USA

    K. Lucas, D. F. Magee, S. Nakajima & N. Veith

Authors
  1. K. Lucas
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  2. D. F. Magee
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  3. S. Nakajima
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  4. N. Veith
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Additional information

Supported by the National Institutes of Health grant No. 2 Rol Am 10285-03.

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Lucas, K., Magee, D.F., Nakajima, S. et al. Pancreozymin/cholecystokinin a physiological mediator of gastric secretory inhibition of duodenal origin. Experientia 24, 570–571 (1968). https://doi.org/10.1007/BF02153778

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  • DOI: https://doi.org/10.1007/BF02153778

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