Influence of systemic ascorbic acid treatment on metabolite levels after regeneration of the corneal epithelium following mild alkali burns

  • M. Reim
  • K. H. Beil
  • G. Kammerer
  • S. Krehwinkel
Article

Abstract

Between 6 and 16 days after mild alkali burns of rabbit eyes, the aqueous humor and corneal stroma ascorbic acid levels were descreased in the untreated animals. Systemic treatment with ascorbate (0.5 g/kg body weight injected daily subcutaneously) raised the reduced ascorbic acid levels to twice the normal values in the aqueous humor, but those of the corneal stroma increased only slightly and remained far below the normal levels. The systemic ascorbate treatment did not improve the healing rate of the corneal epithelium, but increased adenosine triphosphate and diphosphate levels as well as the ATP/ADP ratios. Also, the redox ratio of the glutathione was shifted to a more reduced state

Keywords

Glutathione Ascorbic Acid Adenosine Triphosphate Diphosphate 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • M. Reim
    • 1
  • K. H. Beil
    • 1
  • G. Kammerer
    • 1
  • S. Krehwinkel
    • 1
  1. 1.Department of OphthalmologyFaculty of Medicine, Rheinisch-Westfälische Technische Hochschule AachenAachenGermany

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