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Über diep-Aminosalicylsäure-Festigkeit von Tuberkelbazillen

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Summary

Repeated subculturing ofM. tuberculosis var.hominis was carried out inDubos' medium containing increasing concentrations of PAS. The adapted strains were found to be thirty to sixty times more resistent to PAS than the original ones. On the contrary to this, the sensitivity of the PAS-adapted strains to sulfamethylthiazole was increased. The modified drug sensitivity stayed unchanged in further subcultures in drug-free media. The increased resistence to PAS was not accompanied by lowered virulence.

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References

  1. H. Hurni, Exper.5, 128 (1949).

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  2. R. J. Dubos undG. Middlebrook, Amer. Rev. Tub.61, 334 (1947).

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  3. C. Pierce, R. J. Dubos undG. Middlebrook, J. Exper. Med.86, 159 (1947).

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Authors and Affiliations

  1. Institut für allgemeine Pathologie und Bakteriologie der Universität Szeged, Hungary

    G. Ivánovics

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  1. G. Ivánovics
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Ivánovics, G. Über diep-Aminosalicylsäure-Festigkeit von Tuberkelbazillen. Experientia 6, 108–109 (1950). https://doi.org/10.1007/BF02153378

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  • DOI: https://doi.org/10.1007/BF02153378

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