Summary
A series of grafts of blastopore lips, previously fixed in formol saline and washed, has been carried out. The graft lodged in the blastocœl gave only two inductions, which were moreover atypical, out of 21 cases studied. Each of these two cases shows an atypical neural vesicle composed of patches of neural cells among little-differentiated “neuroidal” cells.
The other 19 cases show the disappearance or reduction of the inducing ability of the organizer; this provokes at the most an epiblastic thickening consisting of closely packed, small polyhedral cells.
An interpretation of the facts is proposed in accordance with the biochemical data. A series of experiments is in progress at present, whose aim is to ascertain the conditions of the reactions set going during the action of the formol on the organizer material.
References
H. Bautzmann, J. Holtfreter, O. Mangold etH. Spemann, Naturwiss.20, 349 (1932).
J. Holtfreter, Arch. Entw. Mech.128, 584 (1933).
D. French etJ.T. Edsall, Adv. in Protein Chemistry11, 277 (1945).
H.S. Olcott etConrat H. Fraenkel, Chem. Rev.41, 151 (1947).
A.T. Ross etW.M. Stanley, J. Gen. Physiol.22, 165 (1938).
W.M. Stanley, J. Exptl. Med.81, 193 (1945).
M.A. Lauffer etM. Wheatley, Arch. bioch.23, 262 (1949).
J. Brachet, Cold Spring Harbor symposia, XII (1947).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lallier, R. Etude de l'induction primaire chez les amphibiens. Experientia 6, 92–93 (1950). https://doi.org/10.1007/BF02153366
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02153366