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Effect of alloxan diabetes and insulin administration on the incidence of pituitary necrosis caused by hexadimethrine bromide in rats

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Zusammenfassung

Während Alloxan Diabetes die Sensitivität der Ratten für die Wirkung des Hexadimethrin-Bromid (HB) nicht steigert, bewirkt Insulinbehandlung eine starke Erhöhung der HB-Empfindlichkeit. Die Mehrzahl der mit Insulin + HB simultan behandelten Ratten starb innerhalb von 2 Tagen, und in den Adenohypophysen zeigten sich häufig Nekrosen. Da die potenzierende Wirkung des Insulins bei Ratten, deren Histamin-Depots durch Vorbehandlung mit Polymyxin und Substanz 48/80 depletiert worden waren, nicht zur Geltung kam, wird angenommen, dass beim HB-potenzierenden Effekt des Insulins auch das Histamin eine Rolle spielt.

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Authors and Affiliations

  1. First Department of Medicine, University Medical School, Szeged, Hungary

    K. Kovács & I. Szijj

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  1. K. Kovács
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  2. I. Szijj
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Kovács, K., Szijj, I. Effect of alloxan diabetes and insulin administration on the incidence of pituitary necrosis caused by hexadimethrine bromide in rats. Experientia 24, 257–258 (1968). https://doi.org/10.1007/BF02152804

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  • DOI: https://doi.org/10.1007/BF02152804

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