Skip to main content
SpringerLink
Log in

p-Xylylenedicyanide and related compounds, weakly cytotoxic nitriles

  • Specialia
  • Pharmacologica
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Extrakte vonV. opulus von schwacher Zelltoxizität enthaltenp-Xylylendinitril. Die Isomeren,m- undp-Cyanohydrozimtsäurenitrile, wurden synthetisiert und auf ihre zelltoxischen Eigenschaften hin untersucht:p-Xylylendinitril erweist sich als am stärksten wirksam.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. C. H. Jarboe, C. M. Schmidt, J. A. Nicholson andK. A. Zirvi, Nature212, 837 (1966).

    Google Scholar 

  2. C. H. Jarboe, K. A. Zirvi, J. A. Nicholson andC. M. Schmidt, J. med. Chem.10, 438 (1967).

    Article  Google Scholar 

  3. H. R. Snyder andG. L. Poos, J. Am. chem. Soc.71, 1395 (1949).

    Google Scholar 

  4. A. F. Titley, J. chem. Soc.1926, 508.

  5. C. G. Smith, S. L. Lummis andJ. E. Grady, Cancer Res.19, 843 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacology Department, School of Medicine, University of Louisville, 40202, Kentucky

    J. A. Nicholson, C. H. Jarboe, W. Haddon & F. W. McLafferty

  2. Chemistry Department, Purdue University, USA, West Lafayette, Indiana

    J. A. Nicholson, C. H. Jarboe, W. Haddon & F. W. McLafferty

Authors
  1. J. A. Nicholson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. H. Jarboe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W. Haddon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. W. McLafferty
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The reported work was supported in part by grants Nos. AM 07147, FR 00354, GM 12755 and GM 33888 from the United States Public Health Service, National Institutes of Health. We are grateful to the management and staff of the Isaac Bernheim Foundation for their helpful assistance with plants.

Inquiries on mass spectra should be directed to F.W.M.; all other inquiries should be directed to C.H.J.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nicholson, J.A., Jarboe, C.H., Haddon, W. et al. p-Xylylenedicyanide and related compounds, weakly cytotoxic nitriles. Experientia 24, 251–252 (1968). https://doi.org/10.1007/BF02152800

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02152800

Keywords

Search

Navigation