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The specificity of histones in nucleated erythrocytes

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  • Chimica. Biochimica. Biophysica
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Riassunto

Dagli eritrociti del pollo, dellaRana cateasbeiana e del pesceCaranx hippos sono stati isolati gli istoni nella ipotesi che gli eritrociti forniti di nucleo contengano una frazione di istone funzionante come repressore permanente della sintesi degli acidi nucleici. Detti istoni sono stati frazionati ed analizzati nella loro composizione in amino-acidi. In tutte e tre le speci su menzionate è stata trovata una frazione relativamente ricca in lisina, arginina, alanina, e serina che è stata denominata F2c. L'assenza di detta frazione negli altri tessuti incluso il midollo osseo indica che la frazione F2c può costituire un repressore genetico permanente.

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Authors and Affiliations

  1. Department of Biochemistry, The University of Texas M. D. Anderson Hospital and Tumor Institute at Houston, 77025, Houston, Texas, USA

    L. J. Edwards & L. S. Hnilica

Authors
  1. L. J. Edwards
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  2. L. S. Hnilica
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Additional information

This investigation was supported by the U.S. Public HEalth Service Grant No. CA-07746, American Cancer Society Grants E-388 and IN-43-F2, and by the Robert A. Welch Foundation Grant G-138.

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Edwards, L.J., Hnilica, L.S. The specificity of histones in nucleated erythrocytes. Experientia 24, 228–229 (1968). https://doi.org/10.1007/BF02152784

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