25-Hydroxycholecalciferol: Effects in idiopathic vitamin D-resistant rickets

Summary

1) HCC is highly active in deficiency rickets. 2) In cases of resistancy to Vitamin D i.e. “pseudo-deficiency” rickets and VDRR, there appears to be a resistancy to doses of HCC that are active in DR. 3) In these two groups of children (PDR and VDRR) when results observed under HCC therapy are compared to results observed, for a same child, under previous Vitamin D therapy, HCC seems to have an activity 5 to 8 times that of weight-equivalent doses of Vitamin D. 4) The doses of HCC used in resistant rickets, 8,000 I.U. to 24,000 I.U./day, for periods lasting 3 to 6 months are well tolerated with no side effects like hypercalcaemia or hypercalciuria.