Abstract
The results of the first clinical trial are presented of the newly designed tumor-seeking radiopharmaceuticall-3-123I-iodo-α-methyltyrosine (IMT) for noncontact detection of malignant eye melanoma by means of a nuclear medicine technique. Eye scintigraphy (ES) was performed on ten outpatients clinically suspected of harboring an intraocular melanoma. ES was carried out with a twin pinhole eye collimator attached to a high resolution gamma camera; 7–10 mCi of IMT was given intravenously to each patient 100–150 min prior to the nuclear medicine investigation. Gamma camera eye scintigraphy and the use of IMT offer a useful noninvasive alternative to the radiophosphorus uptake test. Of the ten patients, five were found not to have a melanoma either clinically or by scintigraphy, three had a melanoma by scintigraphy that was confirmed histologically, and two yielded inconclusive results.
Zusammenfassung
Die erste klinische Anwendung des neuen Radiopharmakonsl-3-123-I-Iodo-α-Methyltyrosin (IMT) zum nuklearmedizinischen Nachweis des malignen Augen-Melanoms wird dargestellt. Es wurden 10 Poliklinik-Patienten mit Verdacht auf ein Melanom des Auges untersucht. Die Augen-Szintigraphie (ES) wird mit einem Zwillings-Lochblenden-Kollimator an einer Gamma-Kamera durchgeführt. 7–10 mCi IMT werden 100–150 min vor der Untersuchung i.v. appliziert. Die Augen-Szintigraphie mit Hilfe einer Gamma-Kamera unter Verwendung des Radiopharmakons IMT eröffnet eine brauchbare, nicht-invasive Untersuchungsmethode als Alternative zum Radiophosphor-Test. Von 10 untersuchten Patienten ließen sich 5 Fälle zusammenfassen, die weder klinisch, noch szintigraphisch ein Melanom hatten. Bei 3 Patienten ließ sich ein Augenmelanom eindeutig nachweisen und histopathologisch bestätigen. Bei 2 Patienten ergaben sich nichtschlüssige Resultate.
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Bockslaff, H., Kloster, G., Dausch, D. et al. Noncontact detection of ocular melanoma withl-3-123I-Iodo-α-methyltyrosine: First clinical results. Graefe's Arch Clin Exp Ophthalmol 219, 149–154 (1982). https://doi.org/10.1007/BF02152302
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DOI: https://doi.org/10.1007/BF02152302