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Isolation of a hypothalamic peptide with TRF (thyreotrophin releasing factor) activityin vitro

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Zusammenfassung

Die elektrophoretisch isolierte Fraktion des hypothalamischen Extraktes, die die adenohypophysären sauren Phosphatasenin vitro und die Sekretion des TSH aktiviert, wurde mittels Gel-Filtration an einer Sephadex G-25 Säule weiter gereinigt. Elektrochromatographische Analyse der gereinigten Fraktion zeigte, dass sie in nativem Zustand Ninhydrin-negativ ist und dass nach der sauren Hydrolyse folgende Aminosäuren aus ihr entstehen: Lysin, Serin, Glycin, Alanin, Asparagin, Glutamsäure, Valin, Isoleucin und Leucin. Dieselbe Fraktion erhöht die Sekretion des TSH aus Rattenhypophysein vitro. Die Fraktion enthält also wahrscheinlich den hypothalamischen Peptid, der die Sekretion des TSH aus der Hypophyse stimuliert (thyreotrophin releasing factor, TRF).

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Literatur

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Authors and Affiliations

  1. Laboratory for Endocrinology and Metabolism, 3rd Medical Clinic, Faculty of General Medicine, Charles University, Prague

    V. Schreiber, M. Rybák, A. Eckertová, V. Jirgl, J. Kočí, Z. Franc & V. Kmentová

  2. Institute of Haematology and Blood Transfusion, Czechoslovakia

    V. Schreiber, M. Rybák, A. Eckertová, V. Jirgl, J. Kočí, Z. Franc & V. Kmentová

  3. Research Institute for Pharmacy and Biochemistry, Prague, Czechoslovakia

    V. Schreiber, M. Rybák, A. Eckertová, V. Jirgl, J. Kočí, Z. Franc & V. Kmentová

Authors
  1. V. Schreiber
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  2. M. Rybák
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  3. A. Eckertová
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  4. V. Jirgl
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  5. J. Kočí
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  6. Z. Franc
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  7. V. Kmentová
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Schreiber, V., Rybák, M., Eckertová, A. et al. Isolation of a hypothalamic peptide with TRF (thyreotrophin releasing factor) activityin vitro. Experientia 18, 338–340 (1962). https://doi.org/10.1007/BF02151867

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  • DOI: https://doi.org/10.1007/BF02151867

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