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Phagocytes, phagocytose et défense de l'organisme contre les infections

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Summary

After the evocation of classic notions about morphology and physiology of free and fixed phagocytes, and their role in the defense of organism against infections, writers give new observations on two principal points.

1. They show that polysaccharids, to which the grampositive bacteria owe their specificity, are the most important agents responsable of the migration of polymorphonuclear leucocytes in inflamed connective tissue.

2. They show that bacterial endotoxins, nature of which is glucido-lipido-polypeptidic, and which are also antigens O “complets” of gram-negative micro-organisms, appear able to stop the coming of polymorphonuclears in inflamed connective tissues. The endotoxins kill not leukocytes; they are not leucocidins, but they prevent diapedesis through a mechanism still obscure. For this reason, they favour the development of infections.

Ultimately, writers tell how the two great theories of immunity, cellular theory ofMetchnikoff and humoral theory of german authors, can mary together: in vivo, phagocytes have the first and also the last word to kill bacteria, but their work is very much easier after opsonization with antibodies.

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References

  1. C. R. Soc. Biol.135, 368, 794, 1529 et 1580 (1941);136, 132, 387 et 642 (1942). Rev. Immunol.6, 307 (1941);7, 33 et 134 (1942). Ann. Institut Pasteur68, 72 (1942).

  2. C. R. Soc. Biol., sous presse.

  3. C. R. Soc. Biol. et Ann. Institut Pasteur, sous presse.

  4. C. R. Soc. Biol.144, 307 (1933); C. R. Acad. Sci.198, 2124 et 2211 (1934).

    Google Scholar 

  5. Voir, en particulier: Rev. Immunol.1, 553 (1935);2, 113 (1936);3, 319 (1937);4, 40, 197 et 469 (1938);6, 86 et 273 (1940/41);7, 16 et 97 (1942). Ann. Institut Pasteur61, 426 (1938). Bull. Soc. Chim. biol.23, 12 (1941). Bull. Acad. Méd.123, 564 et 744 (1940);124, 145 (1941);127, 95, 125 et 162 (1943).

  6. Brit. J. exp. Path.15, 113 (1934). Biochem. J.34, 307 (1940);35, 564 (1941);36, 340 et 355 (1942);37, 601 (1943).

  7. Biochem. J.31, 2003 (1937);34, 169 (1940);35, 1140 (1941). Helv. chim. Acta21, 469 (1938). Brit. J. exp. Path.21, 180 (1940);23, 151 (1942).

    Google Scholar 

  8. Brit. J. exp. Path.20, 83, 109 et 278 (1939). Biochem. J.33, 1709 et 1716 (1939).

  9. J. exp. Med.81, 315, 331 et 349 (1945).

  10. Contrairement aux idées primitivement émises parHeidelberger etAvery, au cours de leurs magnifiques recherches sur les polysaccharides spécifiques des pneumocoques, ces corps ne sont pas de purs haptènes, mais sont doués d'un certain pouvoir antigénique, toujours limité et variable d'une espèce animale à l'autre. Voir, à ce sujet, leRapport surLes Antigènes somatiques et flagellaires des bactéries présenté par l'un de nous devant le 1er Congrès des Microbiologistes de langue française, Paris (1938) (Ann. Institut Pasteur61, 426 (1938).

  11. Bull. Acad. Méd.128, 357 (1944). Ann. Institut Pasteur, sous presse.

  12. J. exp. Med.81, 315, 331 et 349 (1945).

  13. C. R. Soc. Biol.135, 1529 (1941);136, 259 et 387 (1942);137, 96, 209 et 265 (1943);138, 27, 345 et 432 (1944). Rev. Immunol.7, 33 et 134 (1942);8, 30 (1943).

  14. C. R. Soc. Biol.136, 704 (1942);137, 585 (1943). Bull. Acad. Méd.127, 274 (1943);128, 305 (1944). Rev. Immunol.7, 193 (1942);8, 148 (1943);9, 1 (1944/45). Ann. Institut Pasteur71, 168 (1945).

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  1. Paris - Garches

    A. Boivin & A. Delaunay

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  1. A. Boivin
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  2. A. Delaunay
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Boivin, A., Delaunay, A. Phagocytes, phagocytose et défense de l'organisme contre les infections. Experientia 1, 262–272 (1945). https://doi.org/10.1007/BF02151733

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