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An evidence for decrease of energy production in thiamine deficient failing rat heart

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Résumé

La combinaison des substrats — acides pyruvique et fumarique — inhibent le gonflement de mitochondries isolées du coeur de rat, en accord avec le maintien de l'intégrité de la structure mitochondriale par l'adénosine triphosphate produite. On constate la diminution successive de cette inhibition dans des rats déficients en thiamine, par suite du blocage au niveau de la décarboxylation pyruvique. De plus cette carence vitaminique provoque une décroissance graduelle du nombre des mitochondries dans le tissu cardiaque.

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Authors and Affiliations

  1. Department of Medicine (Biochemistry), Tulane University School of Medicine, Seamen's Memorial Laboratory of the USPHS Hospital, New Orleans, Louisiana, U.S.A.

    Mary F. Argus, J. C. Arcos & J. A. Walder

Authors
  1. Mary F. Argus
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  2. J. C. Arcos
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  3. J. A. Walder
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Additional information

Supported by the Grants H-4012 from the National Heart Institute and K62-3 from the Hospital Division, U.S. Public Health Service. We thank MissV. Meyer for the heart size deteminations.

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Argus, M.F., Arcos, J.C. & Walder, J.A. An evidence for decrease of energy production in thiamine deficient failing rat heart. Experientia 18, 519–521 (1962). https://doi.org/10.1007/BF02151609

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