Summary
The determinations of thiamine pyrophosphatase activity were carried out in the liver homogenates of normal guinea-pigs and those poisoned with diphtheria toxin.
The enzyme activity in the toxaemic liver tissue is twice that of normal guinea-pigs. It is supposed that this result may partly explain the increased level of pyruvic acid in the blood of patients with diphtheria. Further studies on this problem are under way.
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Witkowski, S., Filipowicz, B. Thiaminpyrophosphatase bei der experimentellen Diphtherieintoxikation. Experientia 20, 72 (1964). https://doi.org/10.1007/BF02151245
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DOI: https://doi.org/10.1007/BF02151245