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Experientia

, Volume 19, Issue 10, pp 546–547 | Cite as

Verlängerte Überlebenszeit von Hauthomotransplantaten bei Mäusen durch ein Methylhydrazinderivat

  • G. L. Floersheim
Kurze Mitteilungen

Summary

Extended survival of skin homografts in mice was obtained by treatment with a methylhydrazine derivative (1-methyl-2-p-(isopropylcarbamoyl)-benzylhydrazine hydrochloride), representative of a new class of cytotoxic agents. Administration of 100 mg/kg prior to and continuously after the transplantation led to similar survival times as when 300 mg/kg was given daily only after the transplantation. In mice, the compound seems to be more effective than most of the drugs so far known to suppress transplantation immunity.

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Copyright information

© Birkhäuser Verlag 1963

Authors and Affiliations

  • G. L. Floersheim
    • 1
  1. 1.Pharmakologische Anstalt der UniversitätBaselSchweiz

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