The role of β2-adrenoceptors in the IOP-lowering effect of adrenaline

  • H. C. Innemee
  • P. A. van Zwieten
Article

Abstract

The effect of β1-selective, nonselective, and β2-selective adrenoceptor antagonists on intraocular pressure (IOP) and the inhibitory potencies of these drugs on the dipivalyladrenaline-induced reduction of IOP were investigated in the conscious rabbit. All drugs were applied topically on both eyes. From the results it may be concluded that adrenaline reduces IOP by stimulation of β2-adrenoceptors, while β2-adrenoceptor blockade also seems to be an effective mechanism in lowering IOP

Keywords

Public Health Adrenaline Intraocular Pressure Effective Mechanism Inhibitory Potency 

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References

  1. Anderson JA, Davis WL, Wei CP (1980) Site of ocular hydrolysis of a prodrug, dipivefrin, and a comparison of its ocular metabolism with that of the parent compound, epinephrine. Invest Ophthalmol 19:817–823Google Scholar
  2. Bartels SP, Roth HO, Jumblatt MM, Neufeld AH (1980) Pharmacological effects of topical timolol in the rabbit eye. Invest Ophthalmol 19:1189–1197Google Scholar
  3. Bilski A, Dorries S, Fitzgerald JD, Jessup R, Tucker H, Wale J (1980) ICI 118.551, a potent β2-adrenoceptor antagonist. Br J Pharmacol [Suppl] 69:292–293Google Scholar
  4. Bonomi L, Pafetti S, Noya E, Belluci R, Massa F (1979) Comparison of the effects of nine beta-adrenergic blocking agents on intraocular pressure in rabbits. Graefes Arch Clin Exp Ophthalmol 210:1–8Google Scholar
  5. Bromberg BB, Douglas GS, Sears ML (1980) Beta-adrenergic receptors in ciliary processes of the rabbit. Invest Ophthalmol 19:203–207PubMedGoogle Scholar
  6. Cepelik J, Cernohorsky M (1981) The effects of adrenergic agonists and antagonists on the adenylate cyclase in albino rabbit ciliary processes. Exp Eye Res 32:291–299PubMedGoogle Scholar
  7. Coakes RL, Brubaker RF (1978) The mechanism of timolol in lowering intraocular pressure. Arch Ophthalmol 96:2045–2068PubMedGoogle Scholar
  8. Colasanti BK, Trotter RR (1981) Effects of selective β1- and β2-adrenoceptor agonists and antagonists on intraocular pressure in the cat. Invest Ophthalmol 20: 69–76PubMedGoogle Scholar
  9. Gaasterland D, Kupfer C, Ross K, Gabelnick HL (1973) Studies of aqueous humor dynamics in man, III. Measurements in young normal subjects using norepinephrine and isoproterenol. Invest Ophthalmol 12:267–275PubMedGoogle Scholar
  10. Imbs JL, Miesch F, Velly J, LeClerc G, Mann A, Wermuth CG (1977) A potent new β2-adrenoceptor blocking agent. Br J Pharmacol 60:357–362PubMedGoogle Scholar
  11. Innemee HC, de Jonge A, van Meel JCA, Timmermans PBMWM, van Zwieten PA (1981) The effect of selective α1- and α2-adrenoceptor stimulation on intraocular pressure in the conscious rabbit. Naunyn Schmiedebergs Arch Pharmacol 316:294–298PubMedGoogle Scholar
  12. Kass MA, Mandell AI, Goldberg I, Macon Paine J, Becker B (1979) Dipivefrin and epinephrine treatment of elevated intraocular pressure. Arch Ophthalmol 97: 1865–1866PubMedGoogle Scholar
  13. Kaufman PL, Bárány EH (1981) Adrenergic drug effects on aqueous outflow facility following ciliary muscle retrodisplacement in the cynomolgus monkey. Invest Ophthalmol 20:644–652Google Scholar
  14. Langham ME, Diggs E (1972) Quantitative studies of the ocular response to norepinephrine. Exp Eye Res 13:161–171PubMedGoogle Scholar
  15. Langham ME, Diggs E (1974) β-Adrenergic responses in the eyes of rabbits, primates and man. Exp Eye Res 19:281–295PubMedGoogle Scholar
  16. Liu HK, Chiou GCY, Gal LC (1980) Ocular hypotensive effects of timolol in cat eyes. Arch Ophthalmol 98:1467–1469PubMedGoogle Scholar
  17. Nathanson JA (1981) Effects of a potent and specific β2-adrenoceptor antagonist on intraocular pressure. Br J Pharmacol 73:97–100PubMedGoogle Scholar
  18. Pollack IP, Rossi H (1975) Norepinephrine in treatment of ocular hypertension and glaucomas. Arch Ophthalmol 93:173–177PubMedGoogle Scholar
  19. Potter DE, Rowland JM (1978) Adrenergic drugs and intraocular pressure: effects of selective β-adrenergic agonists. Exp Eye Res 27:615–625PubMedGoogle Scholar
  20. Ros FE, Innemee HC, van Zwieten PA (1979) Ocular penetration of β-adrenergic blocking agents. An experimental study with atenolol, metoprolol, timolol and propranolol. Doc Ophthalmol 48:291–301Google Scholar
  21. Sears ML, Neufeld AH (1975) Adrenergic modulation of the outflow of aqueous humor. Invest Ophthalmol 14:83–86PubMedGoogle Scholar
  22. Törnqvist G (1966) Effect of cervical sympathetic stimulation on accomodation in monkeys. An example of a beta-adrenergic inhibitory effect. Acta Physiol Scand 67:363–368PubMedGoogle Scholar
  23. Townsend DJ, Brubaker RF (1980) Immediate effect of epinephrine on aqueous formation in the normal human eye as measured by fluorophotometry. Invest Ophthalmol 19:356–366Google Scholar
  24. Weekers R, Delmarcelle Y, Gastin J (1955) Treatment of ocular hypertension by adrenaline and diverse sympathomimetic amines. Am J Ophthalmol 40:660–672Google Scholar
  25. Yablonski ME, Zimmerman TJ, Waltman SR, Becker B (1978) A fluorometric study of the effect of topical timolol on aqueous humor dynamics. Exp Eye Res 27:135–142PubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH & Co. KG 1982

Authors and Affiliations

  • H. C. Innemee
    • 1
  • P. A. van Zwieten
    • 1
  1. 1.Department of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamAmsterdamThe Netherlands

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