The role of β2-adrenoceptors in the IOP-lowering effect of adrenaline

  • H. C. Innemee
  • P. A. van Zwieten


The effect of β1-selective, nonselective, and β2-selective adrenoceptor antagonists on intraocular pressure (IOP) and the inhibitory potencies of these drugs on the dipivalyladrenaline-induced reduction of IOP were investigated in the conscious rabbit. All drugs were applied topically on both eyes. From the results it may be concluded that adrenaline reduces IOP by stimulation of β2-adrenoceptors, while β2-adrenoceptor blockade also seems to be an effective mechanism in lowering IOP


Public Health Adrenaline Intraocular Pressure Effective Mechanism Inhibitory Potency 


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Copyright information

© Springer-Verlag GmbH & Co. KG 1982

Authors and Affiliations

  • H. C. Innemee
    • 1
  • P. A. van Zwieten
    • 1
  1. 1.Department of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamAmsterdamThe Netherlands

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