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A new finding about the structure-activity relationship of cardiotonic steroids: Lack of cardiotonic action in 15α-hydroxydigitoxigenin

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Zusammenfassung

Es wurde die inotrope Wirkung von 15α-Hydroxy-Digitoxigenin am isolierten Herzen des Frosches und am Herz-Lungen-Präparat des Hundes untersucht. Abweichend von Digitoxigenin hat das 15α-Hydroxy-Derivat keinen Einfluss auf die Kontraktionskraft dieser Präparate.

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ReferencesReferences

  1. Ch. Tamm, Proc. 1st Internat. Pharmacol. Meeting, vol. 3 (Ed. byW. Wilbrandt, Pergamon Press, 1963).

  2. M. Okada andM. Hasunuma, Proc. 82nd Annual Meeting of the Pharmaceutical Society of Japan (1962), p. 219.

  3. H. Ishii, T. Tozyo, andD. Sato, Proc. 82nd Annual Meeting of the Pharmaceutical Society of Japan (1962), p. 218; Chemical and Pharmaceutical Bulletin11, 576 (1963).

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Authors and Affiliations

  1. Department of Pharmacology, Institute for Cardiovascular Diseases, Tokyo Medical and Dental University, Japan

    T. Shigei, M. Katori, H. Murase & S. Imai

  2. Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo, Japan

    T. Shigei, M. Katori, H. Murase & S. Imai

Authors
  1. T. Shigei
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  2. M. Katori
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  3. H. Murase
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  4. S. Imai
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Additional information

A part of the expense of this study was supported by a grant from Hoansha Research Fund.

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Shigei, T., Katori, M., Murase, H. et al. A new finding about the structure-activity relationship of cardiotonic steroids: Lack of cardiotonic action in 15α-hydroxydigitoxigenin. Experientia 20, 572–573 (1964). https://doi.org/10.1007/BF02150301

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  • DOI: https://doi.org/10.1007/BF02150301

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