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Azione di sostanze ad azione antistaminica sulla intossicazione sperimentale da Tiramina e da Tirosina

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Summary

Tyramine and Tyrosine given with food produce in rats a lethal and toxic syndrome which varies in intensity according with the dose given and the age of the rats: toxic and lethal activity is greater in rats just weaned. Substances with antihistaminic activity: RP 32–77 and Antadril, either abolish or inhibit the lethal and toxic activity of Tyramine and Tyrosine, showing a more evident activity when the dose used is greater.

The antitoxic activity of the substances with an anti-histaminic activity seems to be connected with their possible capacity for activating the amino-oxydase of the intestine and viscera of the entire organism.

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References

  1. E. F. Gale, Chem. Ind.19, 721 (1941).

    Google Scholar 

  2. M. X. Sullivan, W. C. Hess eW. H. Sebrell, Publ. Health Pap. Wash. 4783 (1932).

  3. G. J. Martin, Arch. Biochem.1, 937 (1942).

    Google Scholar 

  4. H. M. R. Epps, Biochem. J.39, 37 (1945).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. V. Erspamer eA. Paolini, Arch. Int. pharmacodin.11, 77, 415 (1948).

    Google Scholar 

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Authors and Affiliations

  1. Istituto di I Clinica Pediatrica e Clinica Malattie infettive dell'Università di Roma, Italy

    J. Mulè & L. Garufi

Authors
  1. J. Mulè
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  2. L. Garufi
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Mulè, J., Garufi, L. Azione di sostanze ad azione antistaminica sulla intossicazione sperimentale da Tiramina e da Tirosina. Experientia 6, 433–434 (1950). https://doi.org/10.1007/BF02150130

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  • DOI: https://doi.org/10.1007/BF02150130

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