Skip to main content
SpringerLink
Log in

Activity of Bay n 7133 and Bay 1 9139 in vitro and in experimental murine coccidioidomycosis

  • Original Articles
  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

The activity of two new antifungal azoles, BAY n 7133 and BAY 1 9139, againstCoccidioides immitis was compared with that of ketoconazole in vitro and in experimental murine coccidioidomycosis. Daily intravenous injections were given for 30 days. All mice were autopsied and suspensions of lung, liver and spleen cultured. BAY n 7133 was as active as ketoconazole while BAY 1 9139 was less active. All three drugs were coccidioidostatic only both in vitro and in vivo.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hoeprich, P. D.: Candidosis. In: Hoeprich, P. D. (ed.): Infectious diseases. Harper and Row, Philadelphia, PA, 1983, p. 436–450.

    Google Scholar 

  2. Dismukes, W. E., Stamm, A. M., Graybill, J. R., Craven, P. C., Stevensm, D. A., Stiller, R. L., Sarosi, G. A., Medoff, G., Gregg, C. R., Gallis, H. A., Fields, B. T., Jr., Marier, R. L., Kerkering, T. A., Kaplowitz, L. G., Cloud, G., Bowles, C., Shadomy, S.: Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in fifty-two patients. Annals of Internal Medicine 1983, 98: 13–20.

    PubMed  Google Scholar 

  3. Utz, J. P.: Chemotherapy of systemic mycoses. Medical Clinics of North America 1982, 66: 221–233.

    PubMed  Google Scholar 

  4. Friedman, L., Smith, C. E., Gordon, L. E.: The assay of virulence of coccidioides in white mice. Journal of Infectious Diseases 1955, 96: 311–316.

    Google Scholar 

  5. Hoeprich, P. D., Merry, J. M.: Activity in vitro of two new antifungal azoles. Antimicrobial Agents and Chemotherapy 1984, 25: 339–341.

    PubMed  Google Scholar 

  6. Lawrence, R. M., Huston, A. C., Hoeprich, P. D.: Reproducible method for induction of pulmonary coccidioidomycosis in mice. Journal of Infectious Diseases 1977, 135: 117–119.

    PubMed  Google Scholar 

  7. Levine, H. B.: Direct comparison of oral treatments with BAY-n-7133, BAY-1-9139 and ketaconazle in experimental murine coccidioidomycosis. Sabouraudia 1984, 22: 37–46.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Infectious and Immunologic Diseases, Department of Internal Medicine, University of California Davis Medical Center, 4301 X Street, 95187, Sacramento, California, USA

    P. D. Hoeprich & J. M. Merry

Authors
  1. P. D. Hoeprich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. M. Merry
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoeprich, P.D., Merry, J.M. Activity of Bay n 7133 and Bay 1 9139 in vitro and in experimental murine coccidioidomycosis. Eur. J, Clin. Microbiol. 4, 400–403 (1985). https://doi.org/10.1007/BF02148692

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02148692

Keywords

Search

Navigation