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Pyruvate metabolism in epileptic tuberculous patients

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Résumé

Les auteurs ont étudié la variation de la concentration de l'acide pyruvique dans le sang de 3 tuberculeux épileptiques. Ils ont vérifié l'existence d'un cycle dont le maximum coïncide avec la crise épileptique et dont le minimum la précède et semble la causer. L'effet nuisible de l'isoniazide pour les épileptiques serait dû à la consommation accélerée de l'acide pyruvique, utilisé pour la formation de l'hydrazone respective.

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Authors and Affiliations

  1. Department of Biochemistry, Institute of Phthisiology and Pneumology, University, Rio de Janeiro, Brazil

    R. C. R. Barreto, S. O. Sabino & R. S. Bittencourt

Authors
  1. R. C. R. Barreto
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  2. S. O. Sabino
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  3. R. S. Bittencourt
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Barreto, R.C.R., Sabino, S.O. & Bittencourt, R.S. Pyruvate metabolism in epileptic tuberculous patients. Experientia 18, 280–281 (1962). https://doi.org/10.1007/BF02148235

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