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Isolement et identification du 5β-prégnane 11β, 17α, 21-triol 3, 20-dione (Dihydrocortisol) dans l'urine humaine

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Summary

5β-pregnane 11β, 17α, 21-triol 3, 20-dione (dihydrocortisol) has been isolated and identified in the urine of patients with feminizing adrenal cortical cancer. This steroid showed the same Rf as synthetic dihydrocortisol in six different chromatographic systems. After acetylation, its Rf was the same as that of 21 monoacetate of dihydrocortisol. After bismuthic or chromic oxydation, it had the same chromatographic Rf as 5β-androstane 11β-ol 3, 17-dione and 5β-androstane 3, 11, 17-trione respectively. After chromic oxydation of its acetate, the Rf was the same as that of 21 monoacetate of cortisone.

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Authors and Affiliations

  1. Laboratoire de Chimie biologique, Faculté de Médecine, Paris, France

    J. R. Pasqualini & M. F. Jayle

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  1. J. R. Pasqualini
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  2. M. F. Jayle
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Pasqualini, J.R., Jayle, M.F. Isolement et identification du 5β-prégnane 11β, 17α, 21-triol 3, 20-dione (Dihydrocortisol) dans l'urine humaine. Experientia 18, 273–274 (1962). https://doi.org/10.1007/BF02148230

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  • DOI: https://doi.org/10.1007/BF02148230

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