Skip to main content
SpringerLink
Log in

Thein vitro inhibition of pentobarbital metabolism by chlorpromazine

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Riassunto

Si è osservato che il pentobarbital alla concentrazione di 2 × 10−4 M può inibire per il 44% il metabolismoin vitro della cloropromazina alla medesima concentrazione.

Si è discussa quindi la possibilità di inibire il metabolismoin vitro di alcuni farmaci propria di altre sostanze che vengono metabolizzate in maniera del tutto simile da sistemi enzimatici a livello microsomale epatico.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. B. B. Brodie, J. R. Gillette, andB. N. La Du, Ann. Rev. Biochem.27, 427 (1958).

    Article  CAS  PubMed  Google Scholar 

  2. J. Axelrod, J. Reichenthal, andB. B. Brodie, J. Pharmac. exp. Ther.112, 49 (1954).

    CAS  Google Scholar 

  3. J. R. Fouts andB. B. Brodie, J. Pharmac. exp. Ther,115, 68 (1955).

    CAS  Google Scholar 

  4. J. R. Fouts andB. B. Brodie, J. Pharmac. exp. Ther.116, 480 (1956).

    CAS  Google Scholar 

  5. R. Kato, E. Chiesara, andP. Vassanelli, to be published.

  6. B. B. Brodie, J. J. Burns, L. C. Mark, P. A. Lief, E. Bernstein, andE. M. Papper, J. Pharmac. exp. Ther.109, 26 (1953).

    CAS  Google Scholar 

  7. J. R. Copper andB. B. Brodie, J. Pharmac. exp. Ther.115, 68 (1955).

    Google Scholar 

  8. N. P. Salzman andB. B. Brodie, J. Pharmac. exp. Ther.118, 46 (1956).

    CAS  Google Scholar 

  9. R. Kato, E. Chiesara, andP. Vassanelli, to be published.

  10. H. Remmer, Arch. exp. Path. Pharmak.237, 296 (1959).

    Article  CAS  Google Scholar 

  11. R. Kato, Atti Soc. Lomb. Sci. Med. Biol.14, 783 (1959).

    Google Scholar 

  12. A. H. Conney, C. Davidson, B. Gastel, andJ. J. Burns, J. Pharmac. exp. Ther.130, 1 (1960).

    CAS  Google Scholar 

  13. A. H. Conney, J. A. Michaelson, andJ. J. Burns, J. Pharmac. exp. Ther.132, 202 (1961).

    CAS  Google Scholar 

  14. R. Kato, Med. Exp.3, 95 (1960).

    CAS  Google Scholar 

  15. R. Kato andE. Chiesara, Brit. J. Pharmacol.,18, 29 (1962).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Farmacologia e di Terapia, Università di Milano, Italy

    R. Kato, E. Chiesara & P. Vassanelli

Authors
  1. R. Kato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Chiesara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Vassanelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kato, R., Chiesara, E. & Vassanelli, P. Thein vitro inhibition of pentobarbital metabolism by chlorpromazine. Experientia 18, 269–270 (1962). https://doi.org/10.1007/BF02148227

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02148227

Keywords

Search

Navigation