Gibt es peptisch-tryptische Abbaustufen des Gliadins mit Antigencharakter?

Summary

Peptic and tryptic digestion of gluten and gliadin leaves a part of the substrates unaltered after precipitation at pH 4.5. Complement fixation test of the soluble part remains positive even after autoclaving of this part at pH 4.5, but not so after autoclaving at alkaline reaction. Positive reactions are also given by the components which are not ultrafiltrable while the ultrafiltrates give negative reactions. This means that positive reactions originate from residues of gluten or gliadin respectively. The question posed in the title must be answered in the negative. Products of peptic-tryptic digestion of gliadin do not have antigenic properties.