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Experientia

, Volume 19, Issue 2, pp 108–112 | Cite as

Absolute configuration of the spiro carbon atom of the Erythrina alkaloids: Evidence from optical rotatory dispersion

  • U. Weiss
  • H. Ziffer
Kurze Mitteilungen Studiorum Progressus

Keywords

Carbon Atom Alkaloid Spiro Optical Rotatory Absolute Configuration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

Durch Messung der Rotationsdispersion wurde die bisher unbekannte absolute Konfiguration des Spiro-Kohlenstoffatoms (C-5) der Erythrina-Alkaloide ermittelt. Die Methode beruht auf der Tatsache, dass diese Alkaloide ein nicht-coplanares conjugiertes Dien-System enthalten, und dass die Richtung des Cottoneffektes, welcher von einem solchen System erzeugt wird, von dessen Chiralität abhängt8; diese ist ihrerseits durch die Konfiguration des Moleküls bedingt. Es ergibt sich, dass beide Haupttypen dieser Alkaloide die gleiche absolute Konfiguration von C-5 besitzen und daher derselben sterischen Reihe zugehören.

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Copyright information

© Birkhäuser Verlag 1963

Authors and Affiliations

  • U. Weiss
    • 1
  • H. Ziffer
    • 1
  1. 1.Laboratory of Physical BiologyNational Institute of Arthritis and Metabolic Diseases, National Institutes of HealthBethesdaU.S.A.

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