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The comparative metabolism of ethylene dimethanesulphonate and ethylene dibromide

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  • Chimica. Biochimica. Biophysica
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Zusammenfassung

Äthylenglykol-dimethansulfonat (EDS) wird von der Ratte zu N-Acetyl-S-(β-hydroxyäthyl)-cystein (V), N-Acetyl-S-(β-hydroxyäthyl)-cystein-S-oxyd (VI), und Methansulfonsäure abgebaut. Äthylendibromid (EDB) gibt ausser V und VI, S-(β-Hydroxyäthyl)-cystein (III) und wird weiter zu Kohlendioxyd und anorganischem Sulphat via S-(β-Hydroxyäthyl)-cystein-S-oxyd (IV) abgebaut. Keine der erwähnten Stoffwechselprodukte sind gegen Tumoren oder gegen Spermatogenese wirksam.

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Author information

Authors and Affiliations

  1. Unit of Reproductive Pharmacology of the University, Manchester 13

    A. R. Jones & K. Edwards

  2. Experimental Chemotherapy, Christie Hospital, Manchester 20, England

    A. R. Jones & K. Edwards

Authors
  1. A. R. Jones
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  2. K. Edwards
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Additional information

This work was supported by grants from the Ford Foundation and the Wellcome Trust (A. R. J.) and the British Empire Cancer Campaign for Research (K. E.).

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Jones, A.R., Edwards, K. The comparative metabolism of ethylene dimethanesulphonate and ethylene dibromide. Experientia 24, 1100–1101 (1968). https://doi.org/10.1007/BF02147779

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