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Goldthioglucose and the blood-brain barrier

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  • Anatomica. Histologica. Carcinologica
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Résumé

Après avoir augmenté la perméabilité corticale sang-cerveau chez des rats, on a donné à ces animaux une injection d'aurothioglucose. Aucune lésion due à l'aurothioglucose n'a été decouverte dans aucun des sites de perméabilité accrue. Les résultats montrent que la production de lésions par l'aurothioglucose n'est pas due à une permeabilité non-specifique dans certains sites hypothalamiques; ils confirment la théorie glucostatique qui suggère qu'il existe des glucorécepteurs à affinité définie situés à ces sites.

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Author information

Authors and Affiliations

  1. Department of Psychology, Northeastern University, USA

    E. A. Arees & J. Mayer

  2. Department of Nutrition, Harvard School of Public Health, 02115, Boston, Massachusetts, USA

    E. A. Arees & J. Mayer

Authors
  1. E. A. Arees
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  2. J. Mayer
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Additional information

This research was supported in part by a grant-in-aid from the National Institute of Neurological Diseases and Blindness (No. NB-01941), National Institutes of Health, U.S. Public Health Service; and by the Fund for Research and Teaching, Department of Nutrition, Harvard University.

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Arees, E.A., Mayer, J. Goldthioglucose and the blood-brain barrier. Experientia 24, 1253–1254 (1968). https://doi.org/10.1007/BF02146654

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