Über die Nachweisbarkeit des Äthylesters der 3,3′-Dicumarinylessigsäure und des Dicumarols im menschlichen Blut

Summary

A new analytical method enables the content of Dicoumarol or Tromexan (ethyl ester of 3,3′-dicoumarinylacetic acid) in human blood to be followed. After a single dose, Dicoumarol can be traced in the blood for a longer period than Tromexan. No material amount of Tromexan remains in the blood for more than 36 hours after discontinuation of medication, even after repeated doses. In patients with intact liver functions, with both medicaments the prothrombin level of the blood increases as the Tromexan or Dicoumarol level decreases. Normal prothrombin levels in the blood are generally reached 1–2 days after discontinuation of the medicaments. It is thought that a certain concentration of these compounds must be present in the blood to ensure duration of action of both Dicoumarol or Tromexan.