Skip to main content
SpringerLink
Log in

A refined experimental model for proliferative vitreoretinopathy

  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Animal models of proliferative vitreoretinopathy (PVR) in which the intact vitreous is injected with large numbers of tissue cultured fibroblasts do not accurately represent the disease as it is found in humans. A refined model of PVR is presented, in which the vitreous is compressed and partially detached using intravitreally injected perfluorpropane, followed by injection of 25,000 homologous fibroblasts. Proliferation occurred on the retinal surface, causing retinal detachments with the same frequency as models using greater numbers of cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Algevere P, Kock E (1976) Experimental fibroplasia in rabbit vitreous. Retinal detachment induced by autologous fibroblasts. Graefe's Arch Clin Exp Ophthalmol 199: 215

    Google Scholar 

  • Fastenburg DM, Diddie KR, Dorey K, Ryan SJ (1982) The role of cellular proliferation in an experimental model of massive periretinal proliferation. Am J Ophthalmol 93: 565–572

    PubMed  Google Scholar 

  • Gonvers N, Thresher R (1983) Temporary use of silicone oil in the treatment of proliferative vitreoretinopathy: an experimental study with a new animal model. Graefe's Arch Clin Exp Ophthalmol 221: 46–53

    Google Scholar 

  • Lincoff A, Kreissig I (1981) Intravitreal behavior of perfluorocarbons. Dev Ophthalmol 2: 17

    PubMed  Google Scholar 

  • Sugita G, Tano Y, Machemer R, Abrams G, Claflin A, Fiorentino G (1980) Intravitreal autotransplantation of fibroblasts. Am J Ophthalmol 89: 121–130

    PubMed  Google Scholar 

  • Thresher RJ, Ehrenberg M, Machemer R (1984) Gas mediated vitreous compression: an experimental alternative to mechanized vitrectomy. Graefe's Arch Clin Exp Ophthamol 221: 192–198

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Duke University Eye Center, Durham, Durham, North Carolina, USA

    D. B. Chandler, F. A. Quansah, T. Hida & R. Machemer

Authors
  1. D. B. Chandler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. A. Quansah
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Hida
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Machemer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported by The National Eye Institute, Grant EY02903

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chandler, D.B., Quansah, F.A., Hida, T. et al. A refined experimental model for proliferative vitreoretinopathy. Graefe's Arch Clin Exp Ophthalmol 224, 86–91 (1986). https://doi.org/10.1007/BF02144144

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02144144

Keywords

Search

Navigation