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Experimental intravitreal proliferation and neovascularization in the cynomolgus monkey

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Abstract

An experimental model for intravitreal cellular proliferation was produced by injection of carbon micro- particles into the vitreous of nine cynomolgus monkeys. Eighteen eyes were studied following enucleations 10 weeks after the injections. Histological examinations showed retinal folds or detachments in 16 eyes, while 6 of those had total detachments. Eight eyes contained transvitreal fibro- vascular strands, passing from the optic disk to a “cyclitic” retrolental membrane. The strands and membranes were composed mainly of infiltrates of macrophages, inflammatory cells, fibroblasts, newly formed vessels and van Gieson- staining collagen. Epiretinal proliferation of glial cells also occurred. These experiments indicate that a primarily phagocytic cellular invasion into the vitreous is capable of stimulating further cellular migration and growth and for inducing fibrovascular proliferations.

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Authors and Affiliations

  1. Department of Ophthalmology, Karolinska Institute and Hospital, S-10401, Stockholm, Sweden

    P. Algvere & B. Martini

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  1. P. Algvere
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  2. B. Martini
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Presented at the 1984 meeting of the Club Jules Gonin in Lausanne, Switzerland

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Algvere, P., Martini, B. Experimental intravitreal proliferation and neovascularization in the cynomolgus monkey. Graefe's Arch Clin Exp Ophthalmol 224, 69–75 (1986). https://doi.org/10.1007/BF02144140

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  • DOI: https://doi.org/10.1007/BF02144140

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