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Evaluation of dopexamine hydrochloride as a renoprotective agent during aortic surgery

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Annals of Vascular Surgery

Abstract

Thirty-two patients undergoing elective infrarenal aortic surgery were randomly assigned to receive a perioperative infusion of either dopexamine hydrochloride at a rate of 2 μg/kg/min (n = 15) or 0.9% saline solution as placebo (n = 17). Renal function was monitored by regular measurements of serum creatinine levels. There were significant mean percentage increases in serum creatinine (p < 0.001) at all time points up to 3 days postoperatively in the placebo group but only at 2 and 12 hours in the dopexamine group. It was concluded that dopexamine hydrochloride confers renal protection in patients undergoing aortic reconstruction.

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Authors and Affiliations

  1. Departments of Vascular Surgery and Nephrology, Manchester Royal Infirmary, Manchester, UK

    Mark Welch FRCS, Charles G. Newstead MD, J. Vincent Smyth FRCS, P. Dominic Dodd FRCS & Michael G. Walker ChM

Authors
  1. Mark Welch FRCS
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  2. Charles G. Newstead MD
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  3. J. Vincent Smyth FRCS
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  4. P. Dominic Dodd FRCS
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  5. Michael G. Walker ChM
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Welch, M., Newstead, C.G., Smyth, J.V. et al. Evaluation of dopexamine hydrochloride as a renoprotective agent during aortic surgery. Annals of Vascular Surgery 9, 488–492 (1995). https://doi.org/10.1007/BF02143865

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