Summary
The wound-debriding activity of various types of proteolytic enzymes and proteases from Antarctic krill (multi-enzyme system consisting of both endo- and exopeptidases) was evaluated. The results, based on the enzymatically acieved weight reduction of a necrotic animal material (excised rat skin) in vitro, clearly showed that the multi-enzyme system (krill) had a higher degrading activity than the single enzyme preparation, or that with only a few enzymes. The debriding effect of the krill enzymes was markedly related to the enzyme concentration, resulting in 70–100% substrate degradation after 24 h. The digesting capacity of trypsin reached about 50%, but an increase in concentration of this enzyme did not substantially influence its overall activity. The effect of streptokinase-streptodornase, collagenase and plasmin-desoxyribonuclease was weak (10–20% digested).
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Campbell, D., Hellgren, L., Karlstam, B. et al. Debriding ability of a novel multi-enzyme preparation isolated from Antarctic krill (Euphausia superba). Experientia 43, 578–579 (1987). https://doi.org/10.1007/BF02143592
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DOI: https://doi.org/10.1007/BF02143592