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Pharmacological therapy for proliferative vitreoretinopathy

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Abstract

We developed an animal model in the rabbit eye with intravitreally injected heterotransplanted bovine retinal pigment epithelial cells to test a pharmacological agent which would reduce extracellular matrix formation. Results with 20 and 60 μg ofcis-hydroxyproline showed a 48% decrease in the rate of traction retinal detachments.

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Authors and Affiliations

  1. Department of Ophthalmology, Kentucky Lions Eye Research Institute, University of Louisville School of Medicine, 301 E. Muhammad Ali Blvd., 40202, Louisville, KY, USA

    N. D. Radtke, A. D. Weinsieder & R. J. Ballou

Authors
  1. N. D. Radtke
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  2. A. D. Weinsieder
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  3. R. J. Ballou
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Additional information

Supported in part by National Institute of Health Grant no. 5 R01EY03874-03 and Research to Prevent Blindness, Kentucky Lions Eye Foundation

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Radtke, N.D., Weinsieder, A.D. & Ballou, R.J. Pharmacological therapy for proliferative vitreoretinopathy. Graefe's Arch Clin Exp Ophthalmol 224, 230–233 (1986). https://doi.org/10.1007/BF02143060

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  • DOI: https://doi.org/10.1007/BF02143060

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