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Prediction of risk for pseudoallergic reactions and histamine release in patients undergoing anaesthesia and surgery: A computer-aided model using independence-Bayes

Agents and Actions volume 23, pages 366–369 (1988)Cite this article

Abstract

A computer-aided model for the prediction of pseudoallergic reactions was developed using prospective data collected from 581 patients in a controlled clinical trial examining pseudoallergic reactions to the plasma substitute Haemaccel (outdated formulation). The multivariate analysis of 22 proposed risk factors was performed using Bayes theorem. This enabled the accurate prediction of 86% of the patients who had a systemic reaction. The clinical use of such system would enable a selection of patients to receive the effective prophylactic measure of pretreatment with H1 plus H2-receptor antagonists.

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Affiliations

  1. Institute for Theoretical Surgery, Centre for Operative Medicine I, Philipps University Marburg, D-3550, Marburg

    M. Ennis, C. Ohmann, W. Lorenz & R. Zaczyk

  2. Department of Anaesthesiology, Orthopedic Clinic, Heidelberg, FRG

    B. Schöning

Authors
  1. M. Ennis
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  2. C. Ohmann
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  3. W. Lorenz
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  4. R. Zaczyk
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  5. B. Schöning
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Supported by a grant from the Deutsche Forschungsgemeinschaft (Lo 199/14-2).

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Ennis, M., Ohmann, C., Lorenz, W. et al. Prediction of risk for pseudoallergic reactions and histamine release in patients undergoing anaesthesia and surgery: A computer-aided model using independence-Bayes. Agents and Actions 23, 366–369 (1988). https://doi.org/10.1007/BF02142589

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  • DOI: https://doi.org/10.1007/BF02142589

Keywords

  • Clinical Trial
  • Multivariate Analysis
  • Histamine
  • Systemic Reaction
  • Accurate Prediction