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, Volume 23, Issue 3–4, pp 337–338 | Cite as

Basophil histamine release studies in the evaluation of a new anaesthetic agent

  • D. E. Withington
Histamine in Pathophysiology and Clinical Studies


Propofol (2,6-diisopropylphenol) has recently been introduced into clinical practice as an induction agent. This study evaluated the effect of propofol on basophil histamine release in 13 healthy subjects. No release was demonstrated in 11 subjects. Two subjects released histamine at the highest drug concentration, one also releasing at lower concentrations. Both subjects whose basophils released histamine in response to propofol were anaesthetists using the drug during the course of their practice.


Clinical Practice Healthy Subject Histamine Drug Concentration Anaesthetic Agent 
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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • D. E. Withington
    • 1
    • 2
  1. 1.Chemistry DepartmentUniversity College LondonLondonUK
  2. 2.St. Thomas' HospitalLondonUK

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