The response of intestinal mucosal enzymes which metabolize histamine i.e. diamine oxidase (DAO), histamine N-methyltransferase (HMT), and monoamine oxidase (MAO), to infection withNippostrongylus brasiliensis has been examined in mice and compared to the changes evoked byin vivo administration of compound 48/80. Infection with the parasite resulted in a significant decrease in the concentration of both amine oxidases, followed by recovery of MAO and an overshoot in DAO activity. HMT activity was enhanced at the beginning of infection, then decreased markedly by days 11 to 15, and sharply increased thereafter. Histamine levels were on average only 20% higher than the basal levels over the entire period studied, except on day 4 when they were slightly reduced. Histamine is alleged to be a potential inducing factor for degrading enzymes. Consistently, the histamine releaser 48/80 significantly elevated intestinal mucosal DAO and in some of the mice also increased HMT activity.
Histamine Diamine Monoamine Entire Period Monoamine Oxidase
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L. A. Mitchell, R. B. Wescott and L. E. Perryman,Kinetics of expulsion of the nematode, Nippostrongylus brasiliensis, in mast-cell deficient W/W mice, Parasite Immunol.5, 1–12 (1983).PubMedGoogle Scholar
K. Hatanaka, M. Imakita, S. Go and A. Yamamoto,Effects of degranulation of mast cells on proliferation of mesenchymal cells in the mesentery of mice, Cell Tissue Res.246, 53–56 (1986).CrossRefPubMedGoogle Scholar
W. A. Fogel, M. Ulatowska, K. Adach and Z. Osińska,A sum of 14C putrescine metabolites as a measure of DAO activity. Column chromatography assay, Agents and Actions16, 99–101 (1985).CrossRefPubMedGoogle Scholar
S. H. Snyder and J. Axelrod,Sex differences and hormonal control of histamine methyltransferase activity, Biochim. Biophys. Acta111, 416–421 (1965).PubMedGoogle Scholar
R. J. Wurtman and J. Axelrod,A sensitive and specific assay for the estimation of monoamine oxidase activity, Biochem. Pharmacol.12, 1439–1441 (1963).CrossRefPubMedGoogle Scholar
G. D. Luk, W. P. Vaughan, P. J. Burke and S. B. Baylin,Diamine oxidase as a plasma marker of rat intestinal mucosal injury and regeneration after administration of 1-β-D-arabinofuranosylcytosine, Cancer Res.41, 2334–2337 (1981).PubMedGoogle Scholar
K. Norrby, L. Enerbäck and L. Franzen,Mast cell activation and tissue cell proliferation, Cell Tissue Res.170, 289–303 (1976).CrossRefPubMedGoogle Scholar
P. J. M. Tutton,The influence of histamine on epithelial cell proliferation in the jejunum of the rat, Clin. Exp. Pharmacol. Physiol.3, 369–373 (1976).PubMedGoogle Scholar