Advertisement

Agents and Actions

, Volume 23, Issue 3–4, pp 270–272 | Cite as

Heterogeneity in the response to histamine of isolated dog arteries

  • R. Sotníková
  • P. Gibala
  • J. Dřímal
Histamine and the Cardiovascular System

Abstract

Arterial rings were used to evaluate the differences in the effect of histamine (HIS) on canine dorsal pedal (DPA) and coronary arteries. Moreover, the responses of intact coronary arteries (IA) to HIS were compared with those of arteries isolated from sham operated dogs (SA) and from dogs in the late postinfarction period (PA). DPA responded to HIS added cumulatively with contraction which was potentiated by cimetidine (CIM) and reversed by mepyramine (MEP). IA responded with relaxation potentiated by MEP and reversed by CIM. Under resting conditions, coronary arteries responded to a single concentration of HIS with contraction or relaxation (in IA, SA). In PA, only contractions were seen. Responses of PA were significantly higher than those of IA and SA. It appears that in PA the ratio of H1- and H2-receptors is changed.

Keywords

Coronary Artery Histamine Cimetidine Single Concentration Mepyramine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. [1]
    N. Toda,Mechanisms of histamine-induced relaxation in isolated monkey and dog coronary arteries, J. Pharmacol. exp. Ther.239, 529–535 (1986).PubMedGoogle Scholar
  2. [2]
    R. Ginsburg, M. R. Bristow, N. Kantorowitz, D. S. Baim and D. C. Harrison,Histamine provocation of clinical coronary artery spasm. Implications concerning pathogenesis of variant angina pectoris, Amer. Heart. J.102, 819 (1981).CrossRefPubMedGoogle Scholar
  3. [3]
    A. S. Harris, Y. Aguirra, C. Guerra, R. A. Liptak and J. C. Grigham,Effect of certain local anesthetic drugs upon ventricular tachycardia resulting from myocardial infarction. J. Appl. Physiol.8, 399–431 (1956).PubMedGoogle Scholar
  4. [4]
    M. Konishi, N. Toda and M. Yamamoto,Different mechanisms of action of histamine in isolated arteries of the dog. Br. J. Pharmacol.74, 111–118 (1981).PubMedGoogle Scholar
  5. [5]
    B. Bielkiewicz and D. A. Cook,Evidence for an indirect component of the action of histamine on canine portal vein, Pharmacology29, 233–240 (1984).PubMedGoogle Scholar
  6. [6]
    K. Miwa and N. Toda,Regional differences in the response to vasoconstrictor agents of dog and monkey isolated coronary arteries, Br. J. Pharmacol.82, 295–391 (1984).PubMedGoogle Scholar
  7. [7]
    M. R. Bristow, R. Ginsburg, W. A. Minobe, W. S. Sageman and D. C. Harrison,Receptor density differences may account for local alterations in vascular reactivity, Circulation64, IV-288 (1981).Google Scholar
  8. [8]
    S. Kalsner and R. Richards,Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: A mechanism for coronary spasm, Science223, 1435–1437 (1984).PubMedGoogle Scholar
  9. [9]
    R. C. Ginsburg,Myogenic tone of the isolated human epicardial artery: Regulatory controls, Acta Med. Scand.Suppl. 694, 29–37 (1984).Google Scholar
  10. [10]
    K. Lurie, M. Bristow, R. Ginsburg, W. Minobe, M. Billingham, S. Sageman and D. Harrison,Vascular H 1-receptor upregulation in rabbits fed a high cholesterol diet, CirculationSuppl. IV, 272 (1981).Google Scholar

Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • R. Sotníková
    • 1
  • P. Gibala
    • 1
  • J. Dřímal
    • 1
  1. 1.Institute of Experimental Pharmacology, Centre of Physiological SciencesSlovak Academy of SciencesBratislavaCzechoslovakia

Personalised recommendations