Agents and Actions

, Volume 23, Issue 3–4, pp 237–240 | Cite as

Histamine dependent cyclic AMP generating system in rabbit CNS: Interaction with neuroregulators and forskolin

  • B. Sek
  • A. Sebastjanska
  • J. Z. Nowak
Histamine and the Nervous System


Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in rabbit cerebral cortical slices but not in retinal pieces. The action of HI in the cerebral cortex was not significantly affected by dopamine, serotonin, melatonin and GABA-ergic drugs. Forskolin markedly stimulated cAMP accumulation both in the cerebral cortex and retina. There was a synergistic interaction between HI and forskolin in the cerebral cortex, whereas in the retina HI decreased the forskolin-activated cAMP accumulation.


Dopamine Serotonin Retina Histamine Melatonin 
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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • B. Sek
    • 1
  • A. Sebastjanska
    • 1
  • J. Z. Nowak
    • 1
  1. 1.Department of Biogenic AminesPolish Academy of SciencesŁódź 1Poland

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