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Agents and Actions

, Volume 23, Issue 3–4, pp 237–240 | Cite as

Histamine dependent cyclic AMP generating system in rabbit CNS: Interaction with neuroregulators and forskolin

  • B. Sek
  • A. Sebastjanska
  • J. Z. Nowak
Histamine and the Nervous System

Abstract

Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in rabbit cerebral cortical slices but not in retinal pieces. The action of HI in the cerebral cortex was not significantly affected by dopamine, serotonin, melatonin and GABA-ergic drugs. Forskolin markedly stimulated cAMP accumulation both in the cerebral cortex and retina. There was a synergistic interaction between HI and forskolin in the cerebral cortex, whereas in the retina HI decreased the forskolin-activated cAMP accumulation.

Keywords

Dopamine Serotonin Retina Histamine Melatonin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • B. Sek
    • 1
  • A. Sebastjanska
    • 1
  • J. Z. Nowak
    • 1
  1. 1.Department of Biogenic AminesPolish Academy of SciencesŁódź 1Poland

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